Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells

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paper: Kusnadi, A., Ramírez-Suástegui, C., Fajardo, V., Chee, S. J., Meckiff, B. J., Simon, H., Pelosi, E., Seumois, G., Ay, F., Vijayanand, P. and Ottensmeier, C. H. (2021). Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells. Sci Immunol https://doi.org/10.1126/sciimmunol.abe4782
contributor: Pandurangan Vijayanand; Christian H. Ottensmeier
contributor_organization: La Jolla Institute for Immunology
contributor_email: vijay@lji.org; cottensmeier@lji.org

 

Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome

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paper: Bobcakova, A., Petriskova, J., Vysehradsky, R., Kocan, I., Kapustova, L., Barnova, M., Diamant, Z. and Jesenak, M. (2021). Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome. Front Cell Infect Microbiol https://doi.org/10.3389/fcimb.2021.646688
contributor: Anna Bobcakova, Milos Jesenak
contributor_organization: Comenius University in Bratislava
contributor_email: abobcakova@gmail.com, jesenak@gmail.com

 

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans.

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paper: Arunachalam, P. S., Wimmers, F., Mok, C. K. P., Perera, R. A., Scott, M., Hagan, T., ... & Pulendran B. (2020). Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans. Science, 369(6508), 1210-1220. Chicago
contributor: Bali Pulendran
contributor_organization: Stanford
contributor_email: bpulend@stanford.edu

 

Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID‐19 in type 2 diabetes

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paper: Alzaid, F., Julla, J., Diedisheim, M., Potier, C., Potier, L., Velho, G., Gaborit, B., Manivet, P., Germain, S., Vidal‐Trecan, T., Roussel, R., Riveline, J., Dalmas, E., Venteclef, N. and Gautier, J. (2020). Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID‐19 in type 2 diabetes. EMBO Mol Med https://doi.org/10.15252/emmm.202013038
contributor: Fawaz Alzaid and Jean-François Gautier
contributor_organization: Sorbonne Université, Université de Paris, INSERM, AP-HP

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

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paper: Wang, J., Li, Q., Yin, Y., Zhang, Y., Cao, Y., Lin, X., Huang, L., Hoffmann, D., Lu, M. and Qiu, Y. (2020). Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19. Front Immunol https://www.ncbi.nlm.nih.gov/pubmed/33013872/
contributor: Daniel Hoffmann, Mengji Lu, Yuanwang Qiu
contributor_organization: University of Duisburg-Essen and Jiangnan University
contributor_email: Daniel.Hoffmann@uni-due.de; mengji.lu@uni-due.de; qywang839@126.com

 

Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19

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paper: Haljasmägi, L., Salumets, A., Rumm, A. P., Jürgenson, M., Krassohhina, E., Remm, A., Sein, H., Kareinen, L., Vapalahti, O., Sironen, T., Peterson, H., Milani, L., Tamm, A., Hayday, A., Kisand, K. and Peterson, P. (2020). Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19. Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/33239683/
contributor: Pärt Peterson
contributor_organization: University of Tartu
contributor_email: part.peterson@ut.ee

 

Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients

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paper: Deschler, S., Kager, J., Erber, J., Fricke, L., Koyumdzhieva, P., Georgieva, A., Lahmer, T., Wiessner, J. R., Voit, F., Schneider, J., Horstmann, J., Iakoubov, R., Treiber, M., Winter, C., Ruland, J., Busch, D. H., Knolle, P. A., Protzer, U., Spinner, C. D., Schmid, R. M., Quante, M. and Böttcher, K. (2021). Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients. Viruses https://doi.org/10.3390/v13020241
contributor: Katrin Böttcher
contributor_organization: Technical University of Munich

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

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paper: De Biasi S., Meschiari, M., Gibellini, L., Bellinazzi, C., Borella, R., Fidanza, L., Gozzi, L., Iannone, A., Lo T. D., Mattioli, M., Paolini, A., Menozzi, M., Milić, J., Franceschi, G., Fantini, R., Tonelli, R., Sita, M., Sarti, M., Trenti, T., Brugioni, L., Cicchetti, L., Facchinetti, F., Pietrangelo, A., Clini, E., Girardis, M., Guaraldi, G., Mussini, C. and Cossarizza, A. (2020). Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia. Nat Commun https://doi.org/10.1038/s41467-020-17292-4

Comprehensive mapping of immune perturbations associated with severe COVID-19

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paper: Kuri-Cervantes, L., Pampena, M. B., Meng, W., Rosenfeld, A. M., Ittner, C. A., Weisman, A. R., Agyekum, R. S., Mathew, D., Baxter, A. E., Vella, L. A., Kuthuru, O., Apostolidis, S. A., Bershaw, L., Dougherty, J., Greenplate, A. R., Pattekar, A., Kim, J., Han, N., Gouma, S., Weirick, M. E., Arevalo, C. P., Bolton, M. J., Goodwin, E. C., Anderson, E. M., Hensley, S. E., Jones, T. K., Mangalmurti, N. S., Luning P. E. T., Wherry, E. J., Meyer, N. J. and Betts, M. R. (2020). Comprehensive mapping of immune perturbations associated with severe COVID-19.

SARS-CoV-2 Innate Effector Associations and Viral Load in Early Nasopharyngeal Infection

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paper: Liou, T. G., Adler, F. R., Cahill, B. C., Cox, D. R., Cox, J. E., Grant, G. J., ... & Paine III, R. (2021). SARS‐CoV‐2 innate effector associations and viral load in early nasopharyngeal infection. Physiological reports, 9(4), e14761. https://doi.org/10.14814/phy2.14761
contributor: Ted Liou
contributor_organization: U Utah
contributor_email: ted.liou@utah.edu