paper: Kuri-Cervantes, L., Pampena, M. B., Meng, W., Rosenfeld, A. M., Ittner, C. A., Weisman, A. R., Agyekum, R. S., Mathew, D., Baxter, A. E., Vella, L. A., Kuthuru, O., Apostolidis, S. A., Bershaw, L., Dougherty, J., Greenplate, A. R., Pattekar, A., Kim, J., Han, N., Gouma, S., Weirick, M. E., Arevalo, C. P., Bolton, M. J., Goodwin, E. C., Anderson, E. M., Hensley, S. E., Jones, T. K., Mangalmurti, N. S., Luning P. E. T., Wherry, E. J., Meyer, N. J. and Betts, M. R. (2020). Comprehensive mapping of immune perturbations associated with severe COVID-19. Sci Immunol https://doi.org/10.1126/sciimmunol.abd7114
contributor: Michael Betts
contributor_organization: University of Pennsylvania
contributor_email: betts@pennmedicine.upenn.edu
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- description: Immune profile generated from whole blood in moderate, severe and convalescent COVID-19 compared to uninfected controls.
- exact_source: Figures 1-6
- tissue: PBMC
- immune_exposure: moderate, severe and convalescent COVID-19 infection
- cohort: adults
- comparison: uninfected controls, moderate disease, severe disease, convalescent disease, comparison across groups
- repository_id: https://hpap.pmacs.upenn.edu/
- platform: fcs flow cytometry files
- response_components:
- response_behavior:
PMID
32669287
abstract
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
status
under review
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journal
Sci Immunol
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year of publication
2020