Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

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paper: Agrati, C., Sacchi, A., Bordoni, V., Cimini, E., Notari, S., Grassi, G., Casetti, R., Tartaglia, E., Lalle, E., D’Abramo, A., Castilletti, C., Marchioni, L., Shi, Y., Mariano, A., Song, J., Zhang, J., Wang, F., Zhang, C., Fimia, G. M., Capobianchi, M. R., Piacentini, M., Antinori, A., Nicastri, E., Maeurer, M., Zumla, A. and Ippolito, G. (2020). Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19). Cell Death Differ https://www.ncbi.nlm.nih.gov/pubmed/32514047/
contributor: Giuseppe Ippolito
contributor_organization: Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
contributor_email: giuseppe.ippolito@inmi.it

 

    • description: Massive expansion of MDSCs was observed, up to 90% of total circulating mononuclear cells in patients with severe disease, and up to 25% in the patients with mild disease; the frequency decreasing with recovery.
    • exact_source: Figure 4 and Figure 6
    • tissue: PBMC
    • immune_exposure: COVID-19
    • cohort: adults
    • comparison: severe vs mild disease
    • repository_id:
    • platform: Flow cytometry
    • response_components: Cell type
    • response_behavior: Up

 

PMID
32514047
authors
Agrati, Chiara et al
abstract
SARS-CoV-2 is associated with a 3.4% mortality rate in patients with severe disease. The pathogenesis of severe cases remains unknown. We performed an in-depth prospective analysis of immune and inflammation markers in two patients with severe COVID-19 disease from presentation to convalescence. Peripheral blood from 18 SARS-CoV-2-infected patients, 9 with severe and 9 with mild COVID-19 disease, was obtained at admission and analyzed for T-cell activation profile, myeloid-derived suppressor cells (MDSCs) and cytokine profiles. MDSC functionality was tested in vitro. In four severe and in four mild patients, a longitudinal analysis was performed daily from the day of admission to the early convalescent phase. Early after admission severe patients showed neutrophilia, lymphopenia, increase in effector T cells, a persisting higher expression of CD95 on T cells, higher serum concentration of IL-6 and TGF-β, and a cytotoxic profile of NK and T cells compared with mild patients, suggesting a highly engaged immune response. Massive expansion of MDSCs was observed, up to 90% of total circulating mononuclear cells in patients with severe disease, and up to 25% in the patients with mild disease; the frequency decreasing with recovery. MDSCs suppressed T-cell functions, dampening excessive immune response. MDSCs decline at convalescent phase was associated to a reduction in TGF-β and to an increase of inflammatory cytokines in plasma samples. Substantial expansion of suppressor cells is seen in patients with severe COVID-19. Further studies are required to define their roles in reducing the excessive activation/inflammation, protection, influencing disease progression, potential to serve as biomarkers of disease severity, and new targets for immune and host-directed therapeutic approaches.
status
review complete
curator
reviewer
journal
Cell Death Differ
date review completed
year of publication
2020
In Dashboard
Yes