Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome

Submitted by Anonymous (not verified) on Thu, 06/24/2021 - 00:03

paper: Bouadma, L., Wiedemann, A., Patrier, J., Surénaud, M., Wicky, P., Foucat, E., Diehl, J., Hejblum, B. P., Sinnah, F., de M. E., Lacabaratz, C., Thiébaut, R., Timsit, J. F. and Lévy, Y. (2020). Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome. J Clin Immunol https://doi.org/10.1007/s10875-020-00839-x
contributor: Yves Lévy
contributor_organization: Université Paris-Est Créteil
contributor_email: yves.levy@aphp.fr

- description: Longitudinal analysis of the immune response associated with a fatal case of COVID-19 in Europe.
- exact_source: Figures 2 & 3
- tissue: Serum and PBMC
- immune_exposure: COVID-19 infection
- cohort: Adult 80 years old
- comparison: severe COVID-19 infection vs Healthy donor
- repository_id: NA
- platform: Luminex Bioplex 200 and LSR Fortessa
- response_components: IL-1β, IL-1rα, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8/CXCL8, IL-9, IL-10, IL-12 (p70), IL-13, IL15, IL-17A/CTLA8, Basic FGF (FGF-2), Eotaxin/CCL11, GCSF, GM-CSF, IFN-γ, IP-10/CXCL10, MCP-1/CCL2, MIP- 1α/CCL3, MIP-1β/CCL4, PDGF-BB (PDGF-AB/BB), RANTES/CCL5, TNF-α, VEFG (VEGF-A), IL-1a, IL-2Ra (IL-2R), IL-3, IL-12 (p40), IL-16, IL-18, CTACK/CCL27, GRO-a/CXCL1 (GRO), HGF, IFN-α2, LIF, MCP-3/CCL7, M-CSF, MIF, MIG/CXCL9,b-NGF,SCF, SCGF-b, SDF- 1α,TNF-b/LTA, and TRAIL. CD3 T cells, B cells, NK cells, gammadelta T cells
- response_behavior: up and down

PMID

32829467

authors

Bouadma, Lila et al

abstract

We report a longitudinal analysis of the immune response associated with a fatal case of COVID-19 in Europe. This patient exhibited a rapid evolution towards multiorgan failure. SARS-CoV-2 was detected in multiple nasopharyngeal, blood, and pleural samples, despite antiviral and immunomodulator treatment. Clinical evolution in the blood was marked by an increase (2–3-fold) in differentiated effector T cells expressing exhaustion (PD-1) and senescence (CD57) markers, an expansion of antibody-secreting cells, a 15-fold increase in γδ T cell and proliferating NK-cell populations, and the total disappearance of monocytes, suggesting lung trafficking. In the serum, waves of a pro-inflammatory cytokine storm, Th1 and Th2 activation, and markers of T cell exhaustion, apoptosis, cell cytotoxicity, and endothelial activation were observed until the fatal outcome. This case underscores the need for well-designed studies to investigate complementary approaches to control viral replication, the source of the hyperinflammatory status, and immunomodulation to target the pathophysiological response. The investigation was conducted as part of an overall French clinical cohort assessing patients with COVID-19 and registered in clinicaltrials.gov under the following number: NCT04262921. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10875-020-00839-x) contains supplementary material, which is available to authorized users.

status

review complete

curator

Hancock Lab

reviewer

Aris Floratos

journal

J Clin Immunol

date review completed

Mon, 04/24/2023 - 12:00

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